Trevor N. Collingwood

This paper demonstrates efficient in vivo CRISPR gene editing using a compact Cas12f system delivered via AAV, showing safety and targeting multiple cell types.

This paper identifies and engineers a novel Cas12a nuclease (AiEvo2) with improved specificity and efficacy for human gene editing, including applications in Huntington's disease and CAR-T therapy.

This study identifies and characterizes prokaryotic Argonautes (pAgos) as programmable endonucleases, showing their ability to cleave DNA in vitro with guide RNA/DNA and potential for gene editing.