Tristin Liu

This study identifies DNA sequence variants that influence 3D chromatin conformation and links them to gene expression and disease risk.

This study shows that MLL3/4 proteins regulate chromatin interactions at enhancers by depositing H3K4me1, which recruits Cohesin to facilitate chromatin looping.

The paper introduces a method combining proximity ligation with chromatin immunoprecipitation and sequencing to map long-range chromatin interactions in eukaryotic cells, showing improved sensitivity and accuracy in mouse embryonic stem cells.