Shi-An A. Chen

The paper assesses fitness effects of 9,000 natural variants in yeast signaling pathways, finding that many non-neutral variants show signs of local adaptation.

The paper identifies pervasive gene-by-environment interactions among natural genetic variants in yeast using high-throughput genome editing.

This study shows that MLL3/4 proteins regulate chromatin interactions at enhancers by depositing H3K4me1, which recruits Cohesin to facilitate chromatin looping.