Author

Tyler Stephens

Frederick National Laboratory for Cancer Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Yaroslav TsybovskyiD· 4 shared Amy R. Henry· 3 shared Baoshan ZhangiD· 3 shared Peter D. KwongiD· 3 shared Theodore C. PiersoniD· 3 shared Tongqing ZhouiD· 3 shared Chaim A. SchrammiD· 2 shared Daniel C. DouekiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Yaroslav TsybovskyORCID

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4 papers

Recent·Most cited

Protective immunity against malaria by a nanoparticle CIS43-based junctional vaccine alone or in combination with R21

Prabhanshu Tripathi, Ja‐Hyun Koo, Xuejun Chen, Lais Da Silva Pereira, Marlon Dillon, Baoshan Zhang, Mariah Lofgren, Katelyn T. Nguyen, I‐Ting Teng, Brian G. Bonilla, Sarah Kerscher, Wing‐Pui Kong, Amy R. Henry, Tyler Stephens, Yaroslav Tsybovsky, , Tongqing Zhou

This paper develops a nanoparticle-based junctional vaccine targeting PfCSP and compares its efficacy to the R21 vaccine in reducing malaria liver burden in mice.

npj Vaccines · Apr 27, 2026Peer-reviewedImmunology

Vaccine Elicitation of HIV-1 Neutralizing Antibodies Against Both V2 Apex and Fusion Peptide in Rhesus Macaques

Hongying Duan, Joseph P. Nkolola, Shuishu Wang, Jayeshbhai Chaudhari, I‐Ting Teng, Christy L. Lavine, Danealle K. Parchment, George S. Sellers, Krisha McKee, Sijy J. O'Dell, Misook Choe, Haijuan Du, Baoshan Zhang, Alejandro A. Espinosa Perez, Annika Rössler, , Dan H. Barouch

This study designs a dual-epitope vaccine targeting HIV-1 Env's fusion peptide and V2 apex, showing it elicits neutralizing antibodies against both sites in rhesus macaques.

Cell Reports · Jan 29, 2026Peer-reviewedImmunology

Functional, Immunogenetic, and Structural Convergence in Influenza Immunity between Humans and Macaques

Maya Sangesland, Ning Li, Yaroslav Tsybovsky, Megan D. Rodgers, Julianna Han, Alesandra J. Rodriguez, James A. Ferguson, Amy R. Henry, Sarah D. Smith, Jesmine Roberts-Torres, Rebecca A. Gillespie, Cuiping Liu, Jonah S. Merriam, Tyler Stephens, Connor Williams, , Masaru Kanekiyo

This study shows that macaques can elicit human-like broadly neutralizing antibodies against influenza HA stem regions, with similar immunogenetic and structural features.

Science Translational Medicine · Sep 10, 2025Peer-reviewedImmunology

Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide

Mateo Reveiz, Kai Y. Xu, Myungjin Lee, Shuishu Wang, Adam S. Olia, Darcy R. Harris, Kevin Liu, Tracy W. B. Liu, Andrew J. Schaub, Tyler Stephens, Yiran Wang, Baoshan Zhang, Rick K Huang, Yaroslav Tsybovsky, Peter D. Kwong, Reda Rawi

This study compares vaccine-elicited and naturally elicited antibodies' recognition of HIV-1 fusion peptide sequences, finding that naturally elicited antibodies show greater tolerance to sequence variation.

Frontiers in Immunology · Nov 14, 2024Peer-reviewedImmunology