Daniel C. Douek

The paper identifies endothelial protein C receptor (EPCR) as an entry receptor for Langya and related parahenipaviruses and describes the structural basis of this interaction.

This study identifies Aminopeptidase N as the receptor for hedgehog merbecoviruses and shows restricted cross-species receptor use.

This study shows that antiviral antibody levels remain stable in astronauts during and after long-term spaceflight, despite potential changes in cellular immunity.

This study introduces oxidation-resistant (OXR) antigens by substituting cysteine and methionine with isosteres to improve peptide vaccine manufacturability without compromising immunogenicity.

The paper shows that vaccine imprinting influences susceptibility to SARS-CoV-2 variants in children by linking immune history, antibody neutralization, and infection risk.

This study compares intranasal and intramuscular vaccines, finding that the intranasal Ad4-S vaccine provides more durable and effective immune responses against SARS-CoV-2 in preclinical models.

The paper shows HIV causes collagen deposition in lymphoid tissue early in infection, linked to TGF-β+ macrophages and HIV RNA-producing cells, suggesting early ART may not prevent fibrosis.

This study designs a dual-epitope vaccine targeting HIV-1 Env's fusion peptide and V2 apex, showing it elicits neutralizing antibodies against both sites in rhesus macaques.

The paper identifies and describes Picornaviridae and Caliciviridae viruses in Malagasy fruit bats, finding evidence of cross-continental genetic exchange shaping their diversification.

This study shows that macaques can elicit human-like broadly neutralizing antibodies against influenza HA stem regions, with similar immunogenetic and structural features.

This study shows that transient glycan deletions in SHIVs can induce CD4-binding site broadly neutralizing antibodies in macaques, offering a model for HIV vaccine design.

The paper analyzes RNA-seq data to show that U1 and U2AF splicing efficiencies follow a Weibull distribution, with balanced efficiency maximizing overall splicing efficacy.

This study identifies bat and mink ACE2 as receptors for HKU5 merbecovirus, revealing distinct receptor interactions and highlighting mustelids as potential intermediate hosts.

This study shows that the S2-targeting antibody CC40.8 reduces SARS-CoV-2 viral loads and lower airway inflammation in rhesus macaques, supporting its potential as a broad coronavirus vaccine strategy.

ALIGaToR automates the annotation of immunoglobulin and T cell receptor genomic loci by transferring genetic annotations from a reference to a novel assembly, showing accuracy across species.

This study shows that mucosal adenoviral-vectored vaccines provide durable protection against XBB.1.16 infection in nonhuman primates, outperforming intramuscular boosting in reducing virus replication in both upper and lower airways.

This study shows that Omicron variant-matched boosters after prototype mRNA vaccines induce cross-neutralizing antibodies against SARS-CoV-2 and sarbecoviruses by imprinting prior immune responses.

The paper evaluates the effectiveness of an XBB.1.5 monovalent booster vaccine, showing improved antibody binding and neutralization against SARS-CoV-2 Omicron variants.

This study shows a gorilla adenovirus-based vaccine provides durable immunity against SARS-CoV-2 in both airways of non-human primates, with enhanced protection from aerosol delivery and prime-boost regimens.

The paper compares SARS-CoV-2 antigenicity across assays and in human and animal model sera, finding similar immunodominance patterns and antigenic maps but differences in titer magnitude and assay-specific fold change.

This study investigates how clonal hematopoiesis affects COVID-19 severity and pathophysiology in rhesus macaques, finding prolonged inflammation and higher viral persistence in CH animals.

The paper identifies potent siRNAs against SARS-CoV-2 through RNAi screening, validates their efficacy against variants, and demonstrates their prophylactic potential in a hamster model.

The paper identifies a monocyte-derived transcriptome signature linked to antibody-dependent cellular phagocytosis as a correlate of vaccine-induced protection against HIV-1 in clinical trials.