Dan H. Barouch

This study identifies early innate immune signatures following Ad26.COV2.S vaccination that correlate with vaccine durability and protective efficacy in rhesus macaques and humans.

The paper identifies two distinct phases of immune system changes in ART-suppressed HIV infection using single-cell transcriptomics and proteomics in rhesus macaques.

This study shows that displaying an antigen on adenovirus capsids and encoding it as a transgene enhances both humoral and cellular immune responses in rhesus macaques.

This study evaluates the antiviral activity of four compounds against measles virus in vitro, finding quercetin and isoquercetin to be the most potent therapeutic agents.

This study compares antibody and TCR repertoires in SARS-CoV-2 infectees, vaccinees, and controls to predict neutralizing antibody titers and identifies subtle differences in adaptive immune responses.

This study designs a dual-epitope vaccine targeting HIV-1 Env's fusion peptide and V2 apex, showing it elicits neutralizing antibodies against both sites in rhesus macaques.

This study identifies the origin and dynamics of viral rebound in SIV-infected macaques after ART discontinuation, showing local tissue replication and systemic expansion of clonal lineages.

This study uses scRNA-seq to analyze immune changes in SIV-infected rhesus macaques over time, revealing immune shifts during infection and ART, and identifying transcriptional signatures linked to immune dysregulation and treatment outcomes.

The paper models SIV provirus divergence in CD4+ T cells, finding that short-lived cells harbor more diverged virus, while long-lived cells contain less diverged virus, explaining contradictory prior results on reservoir timing.

This study examines the early spatiotemporal immune response to Ad26 vaccination in mice, showing rapid innate activation in tissues and blood that correlates with later memory CD8+ T cell responses.

This study shows that ZIKV-117, a neutralizing monoclonal antibody, provides complete protection against ZIKV challenge in rhesus macaques at a low dose.

This study identifies compartment-specific antibody correlates of protection against SARS-CoV-2 Omicron in macaques, showing neutralizing antibodies in serum and antibody-dependent cellular phagocytosis in bronchiolar lavage are strongest correlates.

The paper identifies persistent activation of inflammatory pathways in Long Covid patients compared to controls and links acute infection severity to Long Covid development.

The paper analyzes antibody neutralization data from multiple countries to assess how prior exposure to SARS-CoV-2 variants affects neutralization profiles of BA.2.86 and its descendants.

This study evaluates the neutralization escape of the SARS-CoV-2 Omicron subvariant BA.2.86 compared to other variants, finding lower neutralization by antibodies than BA.2 but comparable to circulating variants.

This paper introduces SpaGFT, a graph Fourier transform model for spatial omics data analysis, enabling accurate identification of tissue modules and their functional relationships in spatial transcriptomics and proteomics data.

This paper describes an engineered SARS-CoV-2 RBD variant that shows improved immunogenicity in mice and protective immunity in hamsters.

This study analyzes viral rebound kinetics after immunotherapy in HIV/SIV, finding that vaccines and TLR7-agonists reduce latent reservoir reactivation and boost immune responses.