BiophysicsbioRxiv
Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1
S. van Dorp, R. Qiu, U. B. Choi…·R. S. Lewis
This study investigates the structural dynamics of STIM1's auto-inhibition mechanism using smFRET and crosslinking, revealing how CC1 interacts with CAD to regulate SOCE.
DOI 10.7554/elife.66194