Apolipoprotein-E transforms intracellular Amyloid-β oligomers to a more toxic state
A. Dey, A. Verma, U. Bhaskar, B. Sarkar, M. Kallianpur, V. Visvakarma, A. K. Das, K. Garai, O. Mukherjee, K. Ishii, T. Tahara, S. Maiti
The paper shows ApoE modifies Aβ oligomers to a more toxic form, detectable in live cells, and presents a potential assay for AD drug discovery.
bioRxiv · Sep 3, 2023 · PreprintBiochemistry