B. Sarkar

PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment.

This study shows Mtb induces PPARγ in hepatocytes to create lipid droplets and drug-tolerant environments, contributing to systemic pathogenicity and metabolic impairments during TB infection.

A novel vitamin C analog acts as a potent bio-enhancer to augment the activities of anti-tuberculosis drugs against Mycobacterium tuberculosis

The paper identifies a vitamin C analog, C11, that enhances anti-tuberculosis drug efficacy against M. tuberculosis by reducing mutant generation and increasing ROS production.

Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

This study identifies IL-17 and COX2 as negative regulators of protective immunity in tuberculosis, showing that Ly6G+ granulocytes are a major source of IL-17 and their inhibition reduces bacterial burden and pathology.

A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

Apolipoprotein-E transforms intracellular Amyloid-β oligomers to a more toxic state

The paper shows ApoE modifies Aβ oligomers to a more toxic form, detectable in live cells, and presents a potential assay for AD drug discovery.

Second messenger c-di-AMP regulates multiple antibiotic sensitivity pathways in Mycobacterium smegmatis by discrete mechanisms

This study shows that c-di-AMP modulates antibiotic sensitivity in M. smegmatis by interacting with protein effectors or mRNA 5-UTR regions, leading to differential drug resistance.

Single Photon smFRET. III. Application to Pulsed Illumination

This paper applies a Bayesian nonparametric framework to analyze single photon, single molecule FRET data under pulsed illumination, addressing uncertainties and noise sources in Holliday junction experiments.

Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway

The paper shows pathogenic SMS2 variants disrupt lipid landscapes in the secretory pathway by trapping sphingomyelin in the ER and altering cholesterol and glycerophospholipid distributions.

Exploring different virulent proteins of human respiratory syncytial virus for designing a novel epitope-based polyvalent vaccine: Immunoinformatics and molecular dynamics approaches

This study uses immunoinformatics and molecular dynamics to design a polyvalent epitope-based vaccine against RSV-A and RSV-B, selecting conserved epitopes and validating structural stability.

Infra Red Thermography Reveals Transpirational Cooling in Pearl Millet (Pennisetum glaucum) Plants Under Heat Stress

This study uses infrared thermography to show that heat-stressed pearl millet plants exhibit transpirational cooling at the top, suggesting a mechanism for stress tolerance.

Dynamics of the COVID -19 Related Publications

This paper analyzes the dynamics of COVID-19 related publications across PubMed, Elsevier, and ResearchGate, finding rapid growth in publication rates and geographic author distribution.

The Essential Facts of Wuhan Novel Coronavirus Outbreak in China and Epitope-based Vaccine Designing against COVID-19

This study designs epitope-based subunit vaccines against SARS-CoV-2 using reverse vaccinology and immunoinformatics, selecting the best construct through molecular docking and validating stability and production feasibility.

Curcumin Analogues as the Inhibitors of TLR4 Pathway in Inflammation and Their Drug Like Potentialities: A Computer-based Study

This study identifies curcumin analogues as potential inhibitors of TLR4 pathway proteins using computational analysis, showing better binding affinity than existing drugs.