A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae
P. M. Kaplonek, L. Yao, K. Reppe, F. M. Voss, T. Kohler, F. Ebner, A. Schaefer, U. Blohm, P. Priegue, M. Brautigam, C. L. Pereira, S. G. Parameswarappa, M. Emmadi, P. Menova, M. Witzenrath, , P. H. Seeberger
This paper develops a synthetic glycoconjugate vaccine that combines pneumococcal proteins with a defined oligosaccharide to provide broad protection against multiple serotypes of Streptococcus pneumoniae in animal models.
bioRxiv · Jul 29, 2021Immunology