The conformational landscape of a serpin N-terminal subdomain facilitates folding and in-cell quality control
U. Kaur, K. C. Kihn, H. Ke, W. Kuo, L. M. Gierasch, D. N. Hebert, P. L. Wintrode, D. Deredge, A. Gershenson
This paper investigates how the N-terminal subdomain of serpin 1-antitrypsin (AAT) influences folding and in-cell quality control by maintaining a dynamic conformational landscape.
bioRxiv · Apr 24, 2023 · PreprintBiophysics