H. Ke

The dynamin-related protein Dyn2 is essential for both apicoplast and mitochondrial fission in Plasmodium falciparum

This study shows that PfDyn2 is essential for apicoplast and mitochondrial fission in Plasmodium falciparum, leading to cytokinesis failure and developmental defects.

Multiscale effects of perturbed translation dynamics inform antimalarial design

The paper determines in situ structures of Pf80S ribosomes in Plasmodium falciparum-infected erythrocytes, identifies a bifurcation in translation elongation, and links perturbations to inhibitor effects on ribosome interactions.

Multifunctionality of V-type ATPase during asexual growth and development of Plasmodium falciparum

This study investigates the localization and function of V-type ATPase in Plasmodium falciparum, showing its role in maintaining cytosolic pH and enabling hemoglobin digestion during parasite development.

ZmPILS6 is an auxin efflux carrier required for maize root morphogenesis

This study identifies ZmPILS6 as an auxin efflux carrier in maize that regulates root morphogenesis by controlling auxin distribution and hormone signaling pathways.

Apical annuli are specialised sites of post-invasion secretion of dense granules in Toxoplasma

This study identifies apical annuli in Toxoplasma gondii as specialized sites for post-invasion secretion of dense granules, essential for parasite growth and host cell remodeling.

The conformational landscape of a serpin N-terminal subdomain facilitates folding and in-cell quality control

This paper investigates how the N-terminal subdomain of serpin 1-antitrypsin (AAT) influences folding and in-cell quality control by maintaining a dynamic conformational landscape.

Insights into the function of the chloroplastic ribosome-associated GTPase HflX in Arabidopsis thaliana.

This study investigates the function of HflX in Arabidopsis thaliana, finding it is not essential for growth or stress acclimation but is required for resistance to chloroplast translational stress induced by lincomycin.

Leptospermum extract (QV0) suppresses pleural mesothelioma tumour growth in vitro and in vivo by mitochondrial dysfunction associated apoptosis

This study shows that Leptospermum extract (QV0) reduces pleural mesothelioma tumour growth in vitro and in vivo by inducing mitochondrial dysfunction and apoptosis without adverse effects.

Dosage differences in 12-OXOPHYTODIENOATE REDUCTASE genes modulate wheat primary root growth

This study identifies OPRIII genes in wheat that modulate root architecture and grain yield under water stress through jasmonic acid signaling.

Genetic disruption of isocitrate dehydrogenase arrests the full development of sexual stage parasites in Plasmodium falciparum

This study shows that knocking out isocitrate dehydrogenase (IDH) in Plasmodium falciparum parasites arrests gametocyte development, similar to aconitase knockout, and suggests IDH as a potential target for malaria transmission control.

Transcriptional changes in Plasmodium falciparum upon conditional knock down of mitochondrial ribosomal proteins RSM22 and L23

This study investigates the effects of conditional knockdown of mitochondrial ribosomal proteins RSM22 and L23 in Plasmodium falciparum, revealing distinct transcriptional responses and metabolic defects leading to parasite death.

A plastidial retrograde-signal potentiates biosynthesis of systemic stress response activators

The paper identifies MEcPP as a plastidial retrograde signal that initiates a cascade leading to the biosynthesis of systemic stress response activators in response to biotic and abiotic stresses.

ORA47 is a transcriptional regulator of a general stress response hub

The paper identifies ORA47 as a transcriptional regulator involved in the general stress response by interacting with the RSRE motif and functioning with CAMTA3 and JAZ1.

Reciprocity between retrograde signal and putative metalloprotease reconfigures plastidial metabolism and structure

The paper shows that the retrograde signal MEcPP increases VIR3 abundance, reducing target enzymes and altering plastid metabolism and structure under stress.

Malaria parasites utilize pyrophosphate to fuel an essential proton pump in the ring stage and the transition to trophozoite stage

This study shows that malaria parasites use pyrophosphate to power a proton pump essential for ring stage development and transition to trophozoite stage.

ER exit sites in Drosophila display abundant ER-Golgi vesicles and pearled tubes but no megacarriers

The paper examines ER exit sites in Drosophila, finding pre-cis-Golgi regions and pearled tubes but no megacarriers for ER-Golgi transport.

Recombinant SARS-CoV-2 RBD molecule with a T helper epitope as a built in adjuvant induces strong neutralization antibody response

This study develops a recombinant SARS-CoV-2 RBD molecule fused with a T helper epitope as an adjuvant, showing strong neutralizing antibody response in mice.

Conservation of the Toxoplasma conoid complex proteome reveals a cryptic conoid in Plasmodium that differentiates between blood- and vector-stage zoites

The paper uses spatial proteomics and microscopy to show the conoid is conserved across apicomplexans, including Plasmodium, with structural differences between blood and vector stages.

A dispensable role of mitochondrial fission protein 1 (Fis1) in the erythrocytic development of Plasmodium falciparum

This study shows that Fis1 is not essential for mitochondrial fission in Plasmodium falciparum, suggesting the presence of other fission adaptor proteins.

A subcellular atlas of Toxoplasma reveals the functional context of the proteome

This study maps the subcellular locations of thousands of proteins in Toxoplasma gondii to reveal their functional contexts and evolutionary adaptations.

Retrograde induction of phyB orchestrates ethylene-auxin hierarchy to regulate growth

The paper shows MEcPP coordinates auxin and ethylene signaling via phytochrome B to regulate hypocotyl growth in response to light.

Genetic ablation of the mitochondrial ribosome in Plasmodium falciparum sensitizes the human malaria parasite to antimalarial drugs targeting mitochondrial functions

This study shows that disrupting the mitochondrial ribosome in Plasmodium falciparum makes the parasite more sensitive to drugs targeting mitochondrial functions.

DHH1/DDX6-like RNA helicases maintain ephemeral half-lives of stress-response mRNAs associated with innate immunity and growth inhibition

This study shows that DHH1/DDX6-like RNA helicases in Arabidopsis thaliana regulate the stability of stress-response mRNAs involved in innate immunity and growth inhibition.

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum is dispensable and not the functional target of putative NDH2 quinolone inhibitors

This paper shows that PfNDH2 in Plasmodium falciparum is not essential and that purported NDH2 inhibitors actually target the cytochrome bc1 complex.