Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors
Y. Dunkel, J. Ear, Y. Mittal, B. Lim, L. Liu, M. Holda, U. Nitsche, J. Barbazan, A. Goel, K.-P. Janssen, N. Aznar, P. Ghosh
The paper identifies two Daple/CCDC88C isoforms, showing they cooperatively suppress tumor growth but only the full-length isoform triggers EMT and invasion, with aspirin affecting their expression.
bioRxiv · May 2, 2018Cancer Biology