Cancer BiologybioRxiv
Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors
Y. Dunkel, J. Ear, Y. Mittal…·P. Ghosh
The paper identifies two Daple/CCDC88C isoforms, showing they cooperatively suppress tumor growth but only the full-length isoform triggers EMT and invasion, with aspirin affecting their expression.
DOI 10.1038/s41598-019-48420-w