Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
C. Tindle, G. Katkar, A. Fonseca, S. Taheri, J. Lee, P. Maity, I. Sayed, S.-R. Ibeawuchi, E. Vidales, R. Pranadinata, M. Fuller, D. Stec, M. S. Anandachar, K. Perry, H. Lee, , P. Ghosh
This paper creates a biobank of patient-derived organoids to identify molecular subtypes of Crohn's disease and test subtype-specific therapies.
bioRxiv · Mar 11, 2023Immunology
A. A. Abd El-Hafeez, N. Sun, A. Chakraborty, J. Ear, S. Roy, P. Chamarthi, N. Rajapakse, S. Das, K. E. Luker, T. K. Hazra, G. D. Luker, P. Ghosh
This paper shows that GIV/Girdin modulates DNA damage response by suppressing HR and promoting NHEJ through BRCA1 sequestration and Akt pathway activation.
bioRxiv · Jul 21, 2021 · PreprintCancer Biology
J. Ear, A. Ali Abd El-Hafeez, S. Roy, T. Ngo, N. Rajapakse, J. Choi, S. Khandelwal, M. Ghassemian, L. McCaffrey, I. Kufareva, D. Sahoo, P. Ghosh
The paper examines the evolutionary changes in GIV/Girdin's modularity, interactome, and functions across invertebrates and vertebrates, revealing distinct roles in cancer as tumor suppressor or oncogene.
bioRxiv · Sep 28, 2020 · PreprintBiochemistry
A. Sharma, J. Lee, A. Fonseca, A. Moshensky, T. Kothari, I. S. Ibrahim, S.-R. Ibeawuchi, R. Pranadinata, J. Ear, D. Sahoo, L. Crotty-Alexander, P. Ghosh, S. Das
This study shows that chronic e-cigarette use damages the gut barrier and causes inflammation, driven by non-nicotine chemicals in e-liquids.
bioRxiv · Jul 29, 2020Immunology
J. Ear, A. Saklecha, N. Rajapakse, J. Choi, M. Ghassemian, I. Kufareva, P. Ghosh
The paper shows that tyrosine phosphorylation regulates Daple-PARD3 complex assembly at cell-cell junctions, influencing planar cell polarity during migration.
bioRxiv · Dec 4, 2019 · PreprintCell Biology
Y. Dunkel, A. Reid, J. Ear, N. Aznar, M. Millward, E. Gray, R. Pearce, M. Ziman, P. Ghosh
The paper shows that Daple transcript isoforms V1 and V2 in peripheral blood predict melanoma prognosis, with V2 improving survival and V1 worsening it.
bioRxiv · Jun 17, 2018Cancer Biology
Y. Dunkel, J. Ear, Y. Mittal, B. Lim, L. Liu, M. Holda, U. Nitsche, J. Barbazan, A. Goel, K.-P. Janssen, N. Aznar, P. Ghosh
The paper identifies two Daple/CCDC88C isoforms, showing they cooperatively suppress tumor growth but only the full-length isoform triggers EMT and invasion, with aspirin affecting their expression.
bioRxiv · May 2, 2018Cancer Biology
N. Aznar, N. Sun, Y. Dunkel, J. Ear, M. Buschman, P. Ghosh
This study shows that Akt/PKB enhances non-canonical Wnt signals by phosphorylating Daple, which compartmentalizes β-catenin to cell-cell contact sites, suppressing colony growth.
bioRxiv · Jun 13, 2017Cell Biology