N. Aznar

Soft extracellular matrix drives an endoplasmic reticulum stress-dependent S quiescence underlying molecular traits of pulmonary basal cells

The paper shows that soft extracellular matrix induces S-phase quiescence in progenitor cells via endoplasmic reticulum stress, aligning with molecular traits of pulmonary basal cells.

Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi

This study identifies how receptor tyrosine kinases activate heterotrimeric G proteins through phosphorylation of Gi's interdomain cleft tyrosines, revealing a tyrosine-based signaling mechanism with implications in cancer.

Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Malignant Melanoma

The paper shows that Daple transcript isoforms V1 and V2 in peripheral blood predict melanoma prognosis, with V2 improving survival and V1 worsening it.

Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors

The paper identifies two Daple/CCDC88C isoforms, showing they cooperatively suppress tumor growth but only the full-length isoform triggers EMT and invasion, with aspirin affecting their expression.

Akt/PKB enhances non-canonical Wnt signals by compartmentalizing β-Catenin

This study shows that Akt/PKB enhances non-canonical Wnt signals by phosphorylating Daple, which compartmentalizes β-catenin to cell-cell contact sites, suppressing colony growth.

Convergence of Wnt, Growth Factor and Trimeric G protein signals on Daple

This study identifies Daple as a convergence point for Wnt, growth factor, and G-protein signaling in cancer, showing its role in tumor progression and poor prognosis in colorectal cancer.