BiophysicsbioRxivPreprint
Aging reduces the number and function of L-type calcium channels in the membrane of cardiac pacemaker cells
O. Vivas, M. Baudot, S. Choi…·C. M. Moreno
This study shows that aging reduces L-type calcium channel density, clustering, and open probability in cardiac pacemaker cells, leading to a slowdown in pacemaker rate, which can be reversed pharmacologically.
DOI 10.1101/2022.06.22.497267