Author

A. Adamo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Cotton· 1 shared A. D'Amore· 1 shared A. Enshaei· 1 shared A. Hamblin· 1 shared A. J. Mead· 1 shared A. Krippner-Heidenreich· 1 shared A. Malinova· 1 shared A. Ptasinska· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. Cotton

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A

C. K. Brierley, B. H. Yip, G. Orlando, H. Goyal, S. Wen, J. Wen, M. F. Levine, M. G. Jakobsdottir, A. Rodriguez-Meira, A. Adamo, M. Bashton, A. Hamblin, S. A. Clark, J. O'Sullivan, L. Murphi, , A. J. Mead

The paper identifies chromothripsis-induced amplification of DYRK1A in blast phase MPN as a driver of aggressive disease and a potential therapeutic target.

bioRxiv · Dec 8, 2023 · PreprintCancer Biology

Leukemic stem cells hijack lineage inappropriate signalling pathways to promote their growth

S. G. Kellaway, S. Potluri, P. Keane, H. Blair, P. S. Chin, A. Ptasinska, A. Worker, L. Ames, A. Adamo, D. J. Coleman, N. Khan, S. Assi, A. Krippner-Heidenreich, M. Raghavan, P. N. Cockerill, , C. Bonifer

This study identifies VEGF and IL-5 signalling pathways as aberrantly activated in t(8;21) leukemic stem cells, enabling their growth and relapse.

bioRxiv · Mar 10, 2023Cancer Biology

The axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC

F. Lupo, F. Pezzini, E. Fiorini, A. Adamo, L. Veghini, M. Bevere, C. Frusteri, P. Delfino, S. D'Agosto, S. Andreani, G. Piro, A. Malinova, F. De Sanctis, D. Pasini, R. T. Lawlor, , V. Corbo

This study shows SEMA3A promotes aggressive basal-like PDAC by enhancing metastasis and modulating the tumor microenvironment through macrophage polarization and T cell exclusion.

bioRxiv · Feb 25, 2023Cancer Biology

Mammary Tissue-Derived Extracellular Matrix Hydrogels Reveal the Role of Irradiation in Driving a Pro-Tumor and Immunosuppressive Microenvironment

T. Zhu, S. M. Alves, A. Adamo, X. Wen, K. C. Corn, A. Shostak, S. Johnson, N. D. Shaub, S. E. Martello, B. C. Hacker, A. D'Amore, R. Bardhan, M. Rafat

This study shows that irradiated mammary tissue ECM hydrogels promote TNBC cell proliferation, invasion, and immunosuppression by altering ECM composition and macrophage polarization.

bioRxiv · May 16, 2022Cancer Biology