Translating Membrane Geometry into Protein Function: Multifaceted Membrane Interactions of Human Atg3 Promote LC3-Phosphatidylethanolamine Conjugation during Autophagy
Y. Ye, E. R. Tyndall, V. Bui, M. C. Bewley, G. Wang, X. P. Hong, Y. Shen, J. M. Flanagan, H.-G. Wang, F. Tian
This study determines the solution structure of human Atg3 and shows how its dynamic regions and membrane interactions facilitate LC3-PE conjugation during autophagy.
bioRxiv · Dec 23, 2022 · PreprintBiochemistry