F. Tian

Optimizing ex vivo CAR-T cell-mediated cytotoxicity assay through multimodality imaging

This study optimizes an ex vivo CAR-T cell-mediated cytotoxicity assay using multimodality imaging to improve real-time tracking and throughput.

Biologically Driven In Vivo Occlusion Design Provides a Reliable Experimental Glaucoma Mouse Model

This paper develops a biologically inspired microbead platform for inducing chronic ocular hypertension in mice, leading to retinal ganglion cell loss and visual pathway impairment.

Unveiling the regulatory role of GRP7 in ABA signal-mediated mRNA translation efficiency regulation

This study identifies GRP7 as a key regulator of ABA-mediated translation efficiency in Arabidopsis by modulating pre-rRNA processing and ribosome distribution.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

Nanobead-based single-molecule pulldown for single cells

This paper introduces a nanobead-based single-cell single-molecule pulldown (sc-SiMPull) method that is faster, easier, and more versatile than existing techniques for studying protein-protein interactions in single cells.

Translating Membrane Geometry into Protein Function: Multifaceted Membrane Interactions of Human Atg3 Promote LC3-Phosphatidylethanolamine Conjugation during Autophagy

This study determines the solution structure of human Atg3 and shows how its dynamic regions and membrane interactions facilitate LC3-PE conjugation during autophagy.

Identification of a key genetic factor governing arabinan utilization in the gut microbiome suggests a novel therapeutic target for constipation

The paper identifies the abfA cluster as a key genetic factor for arabinan utilization in gut microbiota, showing its therapeutic potential for constipation through improved gut motility and metabolite production.

Curvature Sensing and Membrane Remodeling of the VPS37A N-terminal Domain during Autophagy

This study identifies two hydrophobic motifs in VPS37A that bind curved membranes, essential for autophagosome biogenesis.

Long-read powered viral metagenomics in the oligotrophic Sargasso Sea

This study uses long-read sequencing to analyze viral communities in the Sargasso Sea, identifying new phage populations and highlighting the importance of long reads for viral genome diversity and function.

ID1 functions as an autonomous phosphate (Pi) regulator upstream of the miR399-ZmPHO2 signaling module in maize

The paper identifies ID1 as an autonomous phosphate regulator that modulates the miR399-ZmPHO2 signaling module to maintain Pi homeostasis in maize.

Tumor subclones, where are you?

This study compares bulk and single-cell mutational analysis to assess tumor clonal structure, finding that bulk analysis underestimates subclonal complexity and dynamic evolution.

S373P Mutation Stabilizes the Receptor-binding Domain of Spike Protein in Omicron and Promotes Binding

The paper investigates the effect of the S373P mutation on the stability and binding ability of the Omicron spike protein's RBD using AFM-SMFS and molecular dynamics simulations.

3D Printable High Performance Conducting Polymer Hydrogel for All-Hydrogel Bioelectronics

This paper develops a bi-continuous conducting polymer hydrogel with high electrical conductivity, stretchability, and fracture toughness for 3D printable bioelectronics.

OsMADS58 stabilizes gene regulatory circuits during rice stamen development

This study identifies OsMADS58's role in stabilizing gene regulatory circuits during rice stamen development using CRISPR knockout and transcriptomic analysis.

Mutation N501Y in RBD of Spike Protein Strengthens the Interaction between COVID-19 and its Receptor ACE2

This study investigates how the N501Y mutation in the SARS-CoV-2 spike protein's RBD enhances its binding to ACE2, contributing to increased transmissibility of variants.

The compound of baicalein, wogonin, and oroxylin-A inhibits EMT in A549 cell line via PI3K/AKT-TWIST1-glycolysis pathway

This study identifies baicalein, wogonin, and oroxylin-A as active compounds in TFAE that inhibit EMT in A549 cells via the PI3K/AKT-TWIST1-glycolysis pathway.

Genome-wide CRISPR activation screen identifies novel receptors for SARS-CoV-2 entry

This study identifies novel SARS-CoV-2 receptors through a CRISPR activation screen, revealing LDLRAD3, TMEM30A, and CLEC4G as functional receptors independent of ACE2.

Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

Synergistic Cytotoxicity Between Cold Atmospheric Plasma and Pyrazolopyrimidinones Against Glioblastoma Cells

The paper tests the synergistic anti-cancer effects of pyrazolopyrimidinones combined with cold atmospheric plasma against glioblastoma cells and identifies two prodrugs that show enhanced cytotoxicity in combination.

Fast and easy single-molecule pulldown assay based on agarose microbeads

This paper introduces a simplified agarose microbead-based SiMPull method that is faster, easier, and more reproducible than the original technique while maintaining similar sensitivity and signal-to-noise ratio.

Capturing in situ Virus-Host Range and Interaction Dynamics through Gene Fusion with epicPCR

The paper uses epicPCR to study virus-host interactions in the Chesapeake Bay, revealing ecological differences between generalist and specialist viruses.

Low dose Cold Atmospheric Plasma induces membrane oxidation, stimulates endocytosis and enhances uptake of nanomaterials in Glioblastoma multiforme cells

Selective Activation of TASK-3-containing K+ Channels Reveals Their Therapeutic Potentials in Analgesia

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.

Surge of Corticocardiac Coupling in SHRSP Rats Exposed to Forebrain Cerebral Ischemia

This study examines brain-heart interactions in SHRSP rats after forebrain ischemia, finding increased corticocardiac coupling linked to autonomic dysfunction and sudden death.