PhysiologybioRxiv
High-fat diet suppresses the positive effect of creatine supplementation on skeletal muscle function by reducing protein expression of IGF-PI3K-AKT-mTOR pathway
R. Ferretti, E. G. Moura, V. C. dos Santos…·N.A.
This study shows that high-fat diet reduces the beneficial effects of creatine supplementation on muscle function by inhibiting the IGF-PI3K-AKT-mTOR pathway in rats.
DOI 10.1371/journal.pone.0199728