Inositol pyrophosphate dynamics reveals control of the yeast PHO starvation program through 1,5-IP8 and the SPX domain of Pho81
V. Chabert, G. Kim, D. Qiu, M. Jamsheer K., L. Michaillat Mayer, H. J. Jessen, A. Mayer, G. Liu
The paper shows that 1,5-IP8 decline triggers the yeast PHO starvation response by inactivating Pho81 through its SPX domain, revealing a unified model of phosphate signaling across eukaryotes.
bioRxiv · Feb 14, 2023 · PreprintCell Biology