A. Mayer

Pools of independently cycling inositol phosphates revealed by pulse labeling with 18O-water

The paper uses 18O-water labeling to study phosphate group dynamics in inositol phosphates across species, revealing distinct pools with different cycling behaviors.

Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer

This study investigates how Vps5 and Vps17 SNX-BAR proteins assemble with Retromer, revealing a PL motif in Vps5 that binds Vps29 and is essential for membrane tubule association and cargo recycling.

Inositol pyrophosphate dynamics reveals control of the yeast PHO starvation program through 1,5-IP8 and the SPX domain of Pho81

The paper shows that 1,5-IP8 decline triggers the yeast PHO starvation response by inactivating Pho81 through its SPX domain, revealing a unified model of phosphate signaling across eukaryotes.

Genetic investigation of honeybee populations in Kazakhstan

This study investigates honeybee populations in Kazakhstan, finding genetic admixture and outbreeding across subspecies due to historical cross-breeding and unregulated mating.

Metabolic consequences of polyphosphate synthesis and imminent phosphate limitation

This study investigates how polyphosphate synthesis and phosphate limitation affect yeast metabolism, revealing that polyphosphate serves metabolic roles beyond phosphate storage.

Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection.

The paper identifies high frequency naive T cell precursors that drive rapid T cell responses during early SARS-COV-2 and LCMV infections.

Retromer oligomerization drives SNX-BAR coat assembly and membrane constriction

This study shows retromer oligomerization drives SNX-BAR coat assembly and membrane constriction, with implications for cellular processes and disease.

Structural plasticity of Atg18 oligomers: organization of assembled tubes and scaffolds at the isolation membrane

This study determines the cryo-EM structures of Atg18 oligomers and their interactions with lipid membranes, revealing their role in coordinating autophagy machinery components.

Measures of epitope binding degeneracy from T cell receptor repertoires

The paper quantifies epitope binding degeneracy in T cell receptors using sequence near-coincidences and shows how paired-chain coincidences reveal antigen-driven selection.

CROP: A Retromer-PROPPIN complex mediating membrane fission in the endo-lysosomal system

The paper identifies the CROP complex as a mediator of membrane fission in the endo-lysosomal system, showing it enhances PROPPIN activity and binds PI(3,5)P2.

Optimal immune specificity at the intersection of host life history and parasite epidemiology

This study examines how life history and epidemiology interact to shape optimal immune strategy using a demographic model of parasite recognition and response.

Heterologous autoimmunity and prokaryotic immune defense

The paper investigates how CRISPR-Cas systems in prokaryotes may cause autoimmunity through cross-reactive spacer targeting, revealing a scaling relationship between spacer length and CRISPR repertoire size.

Early life imprints the hierarchy of T cell clone sizes

This study shows that early life clonal expansions shape the long-term hierarchy of T cell clone sizes in humans, even after decades of aging.

How a well-adapting immune system remembers

The paper models the adaptive immune system as a Bayesian framework that balances new pathogen observations with prior experience to predict future threats and optimize memory repertoire updates.

Receptor crosstalk improves concentration sensing of multiple ligands

This study shows that receptor crosstalk can enhance precision in sensing multiple ligand concentrations by utilizing non-cognate ligand binding events.

Regulation of T cell expansion by antigen presentation dynamics

The paper models T cell expansion dynamics and shows that antigen presentation kinetics regulate the size and specificity of the adaptive immune response.