Reference-based annotation of single-cell transcriptomes identifies a profibrotic macrophage niche after tissue injury
D. Aran, A. P. Looney, L. Liu, V. Fong, A. Hsu, P. J. Wolters, A. Abate, A. J. Butte, M. Bhattacharya
The paper uses scRNA-seq to identify a profibrotic macrophage subtype in injured lung tissue, showing its role in fibrosis and potential as a therapeutic target.
bioRxiv · Mar 22, 2018Immunology