Multiomic Single Cell Sequencing Identifies Stemlike Nature of Mixed Phenotype Acute Leukemia and Provides Novel Risk Stratification
C. A. C. Peretz, V. E. Kennedy, A. Walia, C. L. Delley, A. Koh, E. Tran, I. Clark, C. E. Hayford, C. D'Amato, Y. Xue, K. M. Fontanez, R. Roy, A. C. Logan, A. E. Perl, A. Abate, , C. C. Smith
The paper uses multiomic single-cell profiling to show MPAL blasts have a stem-like transcriptional profile linked to poor prognosis and develops a gene score for clinical risk stratification.
bioRxiv · May 15, 2023 · PreprintCancer Biology