M. Bhattacharya

Deep Profiling of Plasma Proteoforms with Engineered Nanoparticles for Top-down Proteomics

This study uses engineered nanoparticles to enrich low-abundant proteins in human plasma, enabling top-down proteomics to detect proteoforms at lower concentrations and expand proteome depth.

Androgens at the skin surface regulate S. aureus pathogenesis through the activation of agr quorum sensing

This study shows that androgens like testosterone promote S. aureus pathogenesis by activating the agr quorum sensing system, leading to increased virulence and skin infection.

Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

Human endometrial KISS1R inhibits stromal cell decidualization in a manner associated with a reduction in ESR1 levels

This study shows KISS1R inhibits human endometrial stromal cell decidualization by reducing ESR1 levels, which affects embryo invasion and pregnancy success.

'Phase Zero' clinical study platform combining broadband Vis/near-infrared spectroscopy and electrophysiology to study human brain organoid models of neurodevelopmental disorders

The paper evaluates a clinical platform using Vis/NIR spectroscopy and electrophysiology to study E-I ratios and bioenergetics in brain organoids from schizophrenia patients.

Computational modeling of the photon transport, tissue heating, and cytochrome C oxidase absorption during transcranial near-infrared stimulation

This paper models photon transport, tissue heating, and cytochrome c oxidase absorption during transcranial near-infrared stimulation to distinguish photothermal effects from photobiomodulation.

Reference-based annotation of single-cell transcriptomes identifies a profibrotic macrophage niche after tissue injury

The paper uses scRNA-seq to identify a profibrotic macrophage subtype in injured lung tissue, showing its role in fibrosis and potential as a therapeutic target.