Author

A. Hsu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Abate· 1 shared A. J. Butte· 1 shared A. J. Cesare· 1 shared A. P. Looney· 1 shared A. P. Sobinoff· 1 shared A. R. Lefferts· 1 shared C. B. Nelson· 1 shared C. G. Tomlinson· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperImmunology

A. Abate

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

C. B. Nelson, S. Rogers, K. Roychoudhury, Y. S. Tan, C. J. Atkinson, A. P. Sobinoff, C. G. Tomlinson, A. Hsu, R. Lu, E. Dray, M. Haber, J. I. Fletcher, A. J. Cesare, R. S. Hegde, H. A. Pickett

This study identifies PLK1 as a target of EYA4 and EYA1 phosphatases, showing that dephosphorylation of pY445 promotes PLK1 activation and mitosis, with implications for cancer therapy.

bioRxiv · Oct 10, 2022Cell Biology

Dual IgA/IgG family autoantibodies from individuals at-risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum

M. Chriswell, A. R. Lefferts, M. Clay, A. Hsu, J. Seifert, M. L. Feser, M. Maerz, C. Rims, M. Bloom, E. A. Bemis, M. K. Demoruelle, K. D. Deane, E. A. James, J. H. Buckner, W. H. Robinson, , K. A. Kuhn

Subdoligranulum spp. targeted by RA-relevant autoantibodies activate T cells in RA patients and induce autoantibodies and joint swelling in mice.

bioRxiv · Jun 9, 2022 · PreprintImmunology

Inducible overexpression of zebrafish microRNA-722 suppresses chemotaxis of human neutrophil like cells

A. Hsu, S. Liu, K. Brasseale, R. Syahirah, J. Wan, Q. Deng

This study shows that overexpressing zebrafish miR-722 in HL-60 cells reduces chemotaxis and inflammation-related gene expression, suggesting miR-722 suppresses neutrophil migration.

bioRxiv · Mar 14, 2019Immunology

Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel

Y. Yin, M. Wu, A. Hsu, W. Borschel, M. Borgnia, G. Lander, S.-Y. Lee

This study reports cryo-EM structures of TRPM2 channel in intermediate states to elucidate structural transitions during ligand-dependent gating.

bioRxiv · Jan 9, 2019Biochemistry

Structural basis for activation of Dot1L methyltransferase on the nucleosome by histone H2BK120 ubiquitylation

C. J. Anderson, M. R. Baird, A. Hsu, E. H. Barbour, Y. Koyama, M. J. Borgnia, R. K. McGinty

This study determines the cryo-EM structure of Dot1L bound to a ubiquitylated H2BK120 nucleosome, revealing how H2BK120 ubiquitylation activates Dot1L methylation of H3K79.

bioRxiv · Dec 20, 2018 · PreprintBiophysics

Reference-based annotation of single-cell transcriptomes identifies a profibrotic macrophage niche after tissue injury

D. Aran, A. P. Looney, L. Liu, V. Fong, A. Hsu, P. J. Wolters, A. Abate, A. J. Butte, M. Bhattacharya

The paper uses scRNA-seq to identify a profibrotic macrophage subtype in injured lung tissue, showing its role in fibrosis and potential as a therapeutic target.

bioRxiv · Mar 22, 2018Immunology