MicrobiologybioRxiv
Brequinar and Dipyridamole in Combination Exhibits Synergistic Antiviral Activity Against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19
J. F. Demarest, M. Kienle, R. Boytz…·V. S. Kumar
This study shows that combining brequinar and dipyridamole synergistically inhibits SARS-CoV-2 replication in vitro by depleting cellular pyrimidine nucleotides.
DOI 10.1016/j.antiviral.2022.105403