Author

T. Liedl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:drug response / drug discovery· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Heuer-Jungemann· 2 shared H. Ijäs· 2 shared J. Lipfert· 2 shared M. Dass· 2 shared P. J. Kolbeck· 2 shared P. Tinnefeld· 2 shared A. Keller· 1 shared A. Lak· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

A. Heuer-Jungemann

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Author profile →

7 papers

Recent·Most cited

DNA Origami Signal Amplification in LateralFlow Immunoassays

H. Ijäs, J. Trommler, L. Nguyen, S. van Rest, P. C. Nickels, T. Liedl, M. J. Urban

This paper introduces a DNA origami-based signal amplification method for lateral flow immunoassays, significantly improving sensitivity for cardiac troponin I detection in human serum.

bioRxiv · Jul 5, 2024Biophysics

Cooperative dynamics of DNA grafted magnetic nanoparticles optimize magnetic biosensing and coupling to DNA origami

A. Lak, Y. Wang, P. J. Kolbeck, C. Pauer, M. S. Chowdhury, M. Cassani, F. Ludwig, T. Viereck, F. Selbach, P. Tinnefeld, M. Schilling, T. Liedl, J. Tavacoli, J. Lipfert

This study shows that DNA grafting density on magnetic nanoparticles affects their dynamics and biosensing performance, with optimal sensitivity at intermediate densities.

Nanoscale · Jan 1, 2024Peer-reviewedBiochemistry

Site-directed placement of three-dimensional DNA origami

I. V. Martynenko, E. Erber, V. Ruider, M. Dass, G. Posnjak, X. Yin, P. Altpeter, T. Liedl

This paper describes a method for 3D positioning of DNA origami structures on nano-patterned substrates, enabling scalable and versatile fabrication of complex 3D surfaces.

bioRxiv · Dec 11, 2022Biophysics

A DNA origami fiducial for accurate 3D AFM imaging

P. J. Kolbeck, M. Dass, I. Martynenko, R. van Dijk-Moes, K. J. H. Brouwer, A. van Blaaderen, W. Vanderlinden, T. Liedl, J. Lipfert

This paper introduces a DNA origami fiducial to correct AFM image distortions by enabling accurate tip shape reconstruction and improving imaging precision.

bioRxiv · Nov 11, 2022 · PreprintBiophysics

Nanoscale Organization of FasL on DNA Origami as a Versatile Platform to Tune Apoptosis Signaling in Cells

R. M. L. Berger, J. M. Weck, S. M. Kempe, T. Liedl, J. O. Raedler, C. Monzel, A. Heuer-Jungemann

This paper demonstrates DNA origami nanoagents presenting FasL in defined geometries to control apoptosis signaling in cells, showing enhanced efficiency compared to soluble FasL.

Small · Jul 1, 2021Peer-reviewedBiophysics

Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release

H. Ijäs, B. Shen, A. Heuer-Jungemann, A. Keller, M. A. Kostiainen, T. Liedl, J. A. Ihalainen, V. Linko

This study characterizes and optimizes doxorubicin loading into DNA origami nanostructures, revealing rapid binding and variable release profiles influenced by nanostructure design and environmental factors.

bioRxiv · May 13, 2020Biochemistry

DNA origami-based single-molecule force spectroscopy unravels the molecular basis of RNA Polymerase III pre-initiation complex stability

K. Kramm, T. Schroeder, J. Gouge, A. M. Vera, F. B. Heiss, T. Liedl, C. Engel, A. Vannini, P. Tinnefeld, D. Grohmann

The paper uses DNA origami force clamps to study how force affects initiation complex stability in RNA polymerase II and III systems, revealing Bdp1's critical role in RNAP III stability.

bioRxiv · Sep 19, 2019 · PreprintBiophysics