Cell BiologybioRxiv
Insulin-like Growth Factor-1 Regulates the Mechanosensitivity of Chondrocytes by Modulating TRPV4
N. S. Trompeter, J. D. Gardinier, V. M. DeBarros…·R. L. Duncan
This study shows IGF-1 modulates TRPV4 channel activity in chondrocytes by increasing cell stiffness, reducing hypotonic-induced calcium flux and ATP release.
DOI 10.1016/j.ceca.2021.102467