UBE2N is essential for maintenance of skin homeostasis and suppression of inflammation
M. J. Lee, M. Ben Hammouda, W. Miao, A. Okafor, Y. Jin, H. Sun, V. Jain, V. Markovtsov, Y. Diao, S. G. Gregory, J. Y. Zhang
This study shows that UBE2N is crucial for skin homeostasis and inflammation suppression, with its loss causing inflammatory skin defects and identifying IRAK1/4 as a therapeutic target.
bioRxiv · Dec 1, 2023Pathology