V. Jain

Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling

This paper identifies Gli2 as a key driver of immune evasion and immunotherapy resistance in tumors through Wnt and prostaglandin signaling, offering a therapeutic target for combination immunotherapies.

UBE2N is essential for maintenance of skin homeostasis and suppression of inflammation

This study shows that UBE2N is crucial for skin homeostasis and inflammation suppression, with its loss causing inflammatory skin defects and identifying IRAK1/4 as a therapeutic target.

Determining the effects of temperature on the evolution of bacterial tRNA pools

This study investigates how environmental temperature influences the evolution of bacterial tRNA pools and finds that thermophiles have more anticodons, which may increase translation errors.

Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population

This study uses deep transcriptomic analyses to identify a CD34+ neuroectoderm-like population in gangliogliomas, revealing its role as a precursor cell controlling tumor heterogeneity and immune interactions.

Automated microarray for single-cell sorting and collection of lymphocytes following HIV reactivation

This paper uses microarray technology to track and sort HIV-reactivated T-lymphocytes, revealing single-cell reactivation heterogeneity and associated gene expression patterns.

Sex-biased expression is associated with chromatin state in D. melanogaster and D. simulans

The paper investigates the association between chromatin state and sex-biased gene expression in D. melanogaster and D. simulans, finding conserved patterns and species-specific differences.

A circulating T-cell differentiation marker to predict response to immune checkpoint inhibitors

The paper identifies CX3CR1 expression on circulating CD8+ T cells as a biomarker predicting response to immune checkpoint inhibitor therapy in NSCLC patients.

Adhatoda Vasica ameliorates cellular hypoxia dependent mitochondrial dysfunction in acute and severe asthmatic mice.

This study shows Adhatoda Vasica extract reduces hypoxia-induced mitochondrial dysfunction and inflammation in asthma models, offering potential for treating severe steroid-resistant asthma.

Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells

This study shows Sema3A inhibits tumor-specific CD8+ T cell function by inducing cytoskeletal paralysis via NRP1 in the tumor microenvironment.

PDGFRA Defines the Mesenchymal Stem Cell Kaposi’s Sarcoma Progenitors by Enabling KSHV Oncogenesis in an Angiogenic Environment

The paper identifies PDGFRA+ bone marrow-derived mesenchymal stem cells as Kaposi’s sarcoma progenitors and shows pro-angiogenic conditions enable KSHV oncogenesis through epigenetic de-repression.

Cell-intrinsic genetic regulation of peripheral memory-phenotype T cell frequencies

The paper shows memory T cell frequencies are genetically regulated and stable over time, while recently activated cells are influenced by environmental factors.