Mesenchymal Stromal Cell Aging Impairs the Self-Organizing Capacity of Lung Alveolar Epithelial Stem Cells
D. Chanda, M. Rehan, S. R. Smith, K. G. Dsouza, Y. Wang, K. Bernard, D. Kurundkar, V. Memula, K. Kojima, J. A. Mobley, G. Benavides, V. Darley-Usmar, Y.-i. Kim, J. W. Zmijewski, J. Deshane, V. J. Thannickal
This study shows that aging of lung mesenchymal stromal cells impairs the ability of alveolar epithelial stem cells to form 3D organoids, and that reducing Nox4 activity can partially reverse this effect.
bioRxiv · Mar 5, 2021Cell Biology