Author

D. Chanda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

R. Channappanavar· 3 shared R. Ghimire· 3 shared S. More· 3 shared V. J. Thannickal· 2 shared Y. Wang· 2 shared Y.-i. Kim· 2 shared A. Fehr· 1 shared A. Pritchard· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

R. Channappanavar

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma

K. P. Hough, J. L. Trevor, S. Ahmad, Y. Wang, B. K. Chacko, K. F. Goliwas, J. G. Strenkowski, N. B. Bone, Y.-i. Kim, R. Holmes, Y. Liu, S. Vang, A. Pritchard, J. Chin, S. Bodduluri, , J. S. Deshane

This study shows that mitochondrial-containing sEVs from MDRCs activate and polarize Th17 and Th2 cells in asthma, contributing to airway inflammation.

bioRxiv · Apr 30, 2024Immunology

Klebsiella pneumoniae Co-infection Leads to Fatal Pneumonia in SARS-CoV-2-infected Mice

C. Villalva, G. Patil, S. Narayanan, D. Chanda, R. Ghimire, T. Snider, A. Ramachandran, R. Channappanavar, S. More

This study shows that co-infection with SARS-CoV-2 and Klebsiella pneumoniae in mice leads to severe pneumonia and higher mortality.

bioRxiv · Jul 28, 2023Immunology

Toll-like receptor 7 (TLR7)-mediated antiviral response protects mice from lethal SARS-CoV-2 infection

R. Ghimire, R. Shrestha, R. Amaradhi, T. Patton, C. Whitley, D. Chanda, L. Liu, S. More, T. Ganesh, R. Channappanavar

This study shows that TLR7 signaling protects mice from lethal SARS-CoV-2 infection by enhancing antiviral responses and reducing inflammation.

bioRxiv · May 8, 2023Immunology

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice

Y. M. Alhammad, S. Parthasarathy, R. Ghimire, J. J. O'Connor, C. M. Kerr, J. J. Pfannenstiel, D. Chanda, C. A. Miller, R. Unckless, S. Zuniga, L. Enjuanes, S. More, R. Channappanavar, A. Fehr

This study shows that SARS-CoV-2 Mac1 is essential for pathogenesis but not replication, as Mac1-deleted virus replicates normally but induces higher IFN responses and reduced disease in mice.

bioRxiv · Apr 6, 2023 · PreprintMicrobiology

Meta-analysis reveals obesity associated gut microbial alteration patterns and reproducible contributors of functional shift

D. De, D. Chanda

The paper performs a meta-analysis of metagenomic datasets to identify reproducible gut microbial alterations and functional shifts associated with obesity.

bioRxiv · Jun 5, 2022Microbiology

Mesenchymal Stromal Cell Aging Impairs the Self-Organizing Capacity of Lung Alveolar Epithelial Stem Cells

D. Chanda, M. Rehan, S. R. Smith, K. G. Dsouza, Y. Wang, K. Bernard, D. Kurundkar, V. Memula, K. Kojima, J. A. Mobley, G. Benavides, V. Darley-Usmar, Y.-i. Kim, J. W. Zmijewski, J. Deshane, V. J. Thannickal

This study shows that aging of lung mesenchymal stromal cells impairs the ability of alveolar epithelial stem cells to form 3D organoids, and that reducing Nox4 activity can partially reverse this effect.

bioRxiv · Mar 5, 2021Cell Biology