Author

Y.-I. Kim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Y. K. Choi· 4 shared E.-H. Kim· 2 shared J. U. Jung· 2 shared M. A. B. Casel· 2 shared S.-G. Jang· 2 shared S.-M. Kim· 2 shared A. Ensser· 1 shared A. S. Tijsma· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

Y. K. Choi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

SARS-CoV-2 variants show temperature-dependent enhanced polymerase activity in the upper respiratory tract and high transmissibility

S.-M. Kim, E.-H. Kim, M. A. B. Casel, Y.-i. Kim, R. Sun, M.-J. Kwack, J.-S. Yoo, M.-A. Yoo, K.-M. Yoo, S.-G. Jang, R. Rollon, J. H. Choi, J. Gil, K. Eun, H. Kim, , Y. K. Choi

This study shows SARS-CoV-2 variants with P323L or P323L/G671S mutations in NSP12 have enhanced polymerase activity at 33°C and higher transmissibility in ferrets.

bioRxiv · Sep 27, 2022 · PreprintMicrobiology

Therapeutic effect of CT-P59 against SARS-CoV-2 South African variant

S.-Y. Lee, D.-K. Ryu, Y. K. Choi, P. Moore, C. A. v. Baalen, r. song, A. S. Tijsma, T. Gwete-Moyo, M. Kim, Y.-I. Kim, C. Kim, J.-I. Kim, K.-S. Kwon

This study evaluates CT-P59's efficacy against SARS-CoV-2 variants, showing reduced in vitro neutralization but effective in vivo therapeutic potential against the B.1.351 variant.

bioRxiv · Apr 27, 2021Microbiology

Mesenchymal Stromal Cell Aging Impairs the Self-Organizing Capacity of Lung Alveolar Epithelial Stem Cells

D. Chanda, M. Rehan, S. R. Smith, K. G. Dsouza, Y. Wang, K. Bernard, D. Kurundkar, V. Memula, K. Kojima, J. A. Mobley, G. Benavides, V. Darley-Usmar, Y.-i. Kim, J. W. Zmijewski, J. Deshane, V. J. Thannickal

This study shows that aging of lung mesenchymal stromal cells impairs the ability of alveolar epithelial stem cells to form 3D organoids, and that reducing Nox4 activity can partially reverse this effect.

bioRxiv · Mar 5, 2021Cell Biology

Development of spike receptor-binding domain nanoparticle as a vaccine candidate against SARS-CoV-2 infection in ferrets

Y.-I. Kim, D. Kim, K.-M. Yu, H. D. Seo, S.-A. Lee, M. A. B. Casel, S.-G. Jang, S. Kim, W. Jung, C.-J. Lai, Y. K. Choi, J. U. Jung

This study develops a RBD-based nanoparticle vaccine against SARS-CoV-2 that protects ferrets from infection and reduces viral load.

bioRxiv · Jan 28, 2021Immunology

Single-cell Transcriptome of Bronchoalveolar Lavage Fluid Reveals Dynamic Change of Macrophages During SARS-CoV-2 Infection in Ferrets

J. S. Lee, J.-Y. Koh, K. Yi, Y.-I. Kim, S.-J. Park, E.-H. Kim, S.-M. Kim, S. H. Park, Y. S. Ju, Y. K. Choi, S.-H. Park

This study uses single-cell RNA sequencing to track macrophage dynamics in SARS-CoV-2-infected ferrets over time, revealing distinct subpopulations and functional changes.

bioRxiv · Nov 18, 2020Immunology

Calotropis gigantea extract induces apoptosis through extrinsic/intrinsic pathways and upregulation of reactive oxygen species in non-small-cell lung cancer cells

D.-Y. Yoon, J. Lee, H. Jang, Y. Bak, J.-W. Shin, H. Jin, Y.-I. Kim, H. W. Ryu, R. Oh

This study shows that Calotropis gigantea extract induces apoptosis in NSCLC cells via extrinsic and intrinsic pathways and ROS generation.

bioRxiv · Oct 11, 2018Cancer Biology