Loss of IRF5 increases ribosome biogenesis leading to alterations in mammary gland architecture and metastasis
Z. Brune, D. Li, S. Song, D. I. Li, I. Castro, R. Rasquinha, M. Rice, Q. Guo, K. Kampta, M. Moss, M. Lallo, E. Pimenta, C. Somerville, M. Lapan, V. Nelson, , B. J. J. Barnes
This study shows that loss of IRF5 predicts metastasis and survival in breast cancer and reveals its role in regulating ribosome biogenesis and tumor progression.
bioRxiv · May 1, 2023 · PreprintCancer Biology