Author

Z. Brune

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1

Frequent Co-Authors

P. Tsvetkov· 2 shared S. Lindquist· 2 shared A. Detappe· 1 shared A. Tsherniak· 1 shared B. J. J. Barnes· 1 shared C. Dos Santos· 1 shared C. Kayatekin· 1 shared C. Somerville· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

P. Tsvetkov

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Loss of IRF5 increases ribosome biogenesis leading to alterations in mammary gland architecture and metastasis

Z. Brune, D. Li, S. Song, D. I. Li, I. Castro, R. Rasquinha, M. Rice, Q. Guo, K. Kampta, M. Moss, M. Lallo, E. Pimenta, C. Somerville, M. Lapan, V. Nelson, , B. J. J. Barnes

This study shows that loss of IRF5 predicts metastasis and survival in breast cancer and reveals its role in regulating ribosome biogenesis and tumor progression.

bioRxiv · May 1, 2023 · PreprintCancer Biology

Transient Hsp90 suppression promotes a heritable change in protein translation

P. Tsvetkov, Z. Brune, T. J. Eisen, S. Heinrich, G. A. Newby, E. Hallacli, C. Kayatekin, D. Pincus, S. Lindquist

The paper shows that transient Hsp90 suppression causes a heritable change in protein translation that persists across generations.

bioRxiv · Jul 10, 2018Cell Biology

Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress

P. Tsvetkov, A. Detappe, K. Cai, H. R. Keys, Z. Brune, W. Ying, P. Thiru, M. Reidy, G. Kugener, A. Tsherniak, S. Santagata, L. Whitesell, J. L. Markley, I. M. Ghobrial, S. Lindquist

This study identifies FDX1 inhibition as a strategy to prevent proteasome inhibitor resistance in cancer by targeting mitochondrial Fe-S cluster biosynthesis.

bioRxiv · Mar 24, 2018Cancer Biology