Cyld aborts hyperactivation of synovial fibroblasts in inflammatory arthritis by regulating the TAK1/IKK2 signaling axis
V. Rinotas, K. Iliaki, L. Pavlidi, T. Meletakos, G. Mosialos, M. Armaka
This study shows that Cyld regulates TNF-induced hyperactivation of synovial fibroblasts in arthritis by controlling the TAK1/IKK2 signaling axis, thereby preventing inflammation and joint destruction.
bioRxiv · Nov 13, 2023Immunology