ImmunologybioRxiv
Cyld aborts hyperactivation of synovial fibroblasts in inflammatory arthritis by regulating the TAK1/IKK2 signaling axis
V. Rinotas, K. Iliaki, L. Pavlidi…·M. Armaka
This study shows that Cyld regulates TNF-induced hyperactivation of synovial fibroblasts in arthritis by controlling the TAK1/IKK2 signaling axis, thereby preventing inflammation and joint destruction.
DOI 10.1038/s41419-024-06966-2