MORC2 restriction factor silences HIV proviral expression
A. Lasserre, S. Marie, M. Morel, M. M. Martin, A. Legrand, V. Vauthier, A. Cimarelli, L. Etienne, F. Margottin-Goguet, R. Matkovic
This study identifies MORC2 as a negative regulator of HIV-1 provirus expression, showing it is recruited to the provirus locus and required for HUSH-mediated silencing.
bioRxiv · Mar 29, 2023 · PreprintMicrobiology