M. Morel

Deciphering lentiviral Vpr/Vpx determinants required for HUSH and SAMHD1 antagonism highlights the molecular plasticity of these evolutionary conflicts

This study identifies viral determinants in Vpr and Vpx proteins that enable antagonism of SAMHD1 and HUSH, revealing molecular plasticity in lentiviral adaptation to host restrictions.

Accurate Detection of Convergent Mutations in Large Protein Alignments with ConDor

The paper introduces ConDor, a method to detect convergent mutations in protein alignments by combining phylogenetic simulation and comparative analysis, showing improved accuracy on large datasets.

MORC2 restriction factor silences HIV proviral expression

This study identifies MORC2 as a negative regulator of HIV-1 provirus expression, showing it is recruited to the provirus locus and required for HUSH-mediated silencing.

DNA-encoded immunoassay in picoliter drops: a minimal cell-free approach

This paper introduces a DNA-encoded immunoassay in picoliter drops that enables rapid, purification-free detection of antigens using cell-free synthesis of antibodies.

Conditional ERK3 overexpression cooperates with PTEN deletion to promote lung adenocarcinoma formation in mice

Binding to DCAF1 distinguishes TASOR and SAMHD1 degradation by HIV-2 Vpx

This study identifies how HIV-2 Vpx distinguishes between degrading TASOR and SAMHD1 by interacting with DCAF1, revealing a ternary complex and key Vpx mutants affecting TASOR degradation.