Developmental BiologybioRxiv
The transcriptional repressor REST is a major negative regulator of endocrine differentiation during pancreas organogenesis
Meritxell Rovira, Goutham Atla, Miguel Angel Maestro…·Jorge P. Ferrer
The paper shows REST inhibits pancreatic endocrine differentiation in mice, zebrafish, and human organoids, identifying it as a key negative regulator.