Victor Nizet

This study shows that monounsaturated fatty acid biosynthesis is essential for streptococcal growth, stress tolerance, and virulence, with species-specific effects on pathogenesis.

This study examines how maternal exposure to ampicillin or amoxicillin/clavulanate affects neonatal gut microbiome, metabolome, and vaccine responses to PCV20.

This study shows that vaccine efficacy against Staphylococcus aureus alpha toxin decreases in aged mice due to reduced ADAM10 activity and myeloid cell dysfunction.

This paper uses pangenome decomposition to reveal lineage-specific immune-evasion and virulence architectures in group A Streptococcus, showing that virulence factors are organized into distinct modules.

The paper introduces microbiomeMASST, a metadata network graph linking metabolites across datasets, enabling cross-study analysis of microbial metabolites and their biological context.

This paper identifies the pneumococcal S protein as essential for resisting host antimicrobials by coordinating cell wall modification and repair through interactions with PBP1a and PgdA.

This study shows glycerol inhibits lactose-dependent growth in Streptococcus pyogenes without affecting transcription, while lactose induces distinct transcriptional responses.

This study identifies platelet factor 4 (PF4) as a mediator of endothelial antimicrobial activity, enhancing bacterial clearance and improving sepsis outcomes through clathrin-mediated endocytosis and reduced immunothrombosis.

This study shows that Group B Streptococcus (GBS) causes meningitis by lysing endothelial cells in zebrafish, not through transcytosis, and identifies inflammation and clotting as key factors in brain invasion.

This study examines how maternal ampicillin exposure during pregnancy and postpartum affects fecal microbiome and metabolic profiles, linking these changes to increased offspring weight gain.

The paper identifies mutations in S. aureus USA300 strains that affect gene regulation by combining genetic association testing with transcriptional regulatory network reconstruction.

This study uses a zebrafish model to show mycobacteria cause transient vascular occlusions and ischemia during early brain infection, establishing a model for TBM vascular complications.

This study shows that Tamm-Horsfall protein enhances neutrophil NETosis during UTI by modulating respiratory chain, granules, and chromatin remodeling pathways.

The paper uses pattern-based genome mining to discover indanopyrrole A, a novel antibiotic from a marine Streptomyces, and links it to an orphan biosynthetic gene cluster.

The paper introduces SkinCom, a synthetic skin microbial community, which enables reproducible in vitro and in vivo studies of the human skin microbiome and recapitulates 65.6% of in vitro responses in a human trial.

This paper develops a doxycycline-inducible CRISPRi system for GAS to enable efficient gene repression and presents a genome browser for GAS genetic features.

This study examines how ampicillin exposure via different routes affects bile acid metabolism in mice, finding significant changes in maternal bile acids and increased infant weight.

This study uses pharmacoproteomics to analyze treatment responses in a murine sepsis model, identifying distinct response patterns and drug interactions across organs and time.

This study shows that human neutrophils reposition inflammatory genes to a transcriptionally permissive compartment within hours of microbial exposure, enabling rapid transcriptional responses.