MicrobiologyPLoS PathogensPeer-reviewed
The "DDVF" motif used by viral and bacterial proteins to hijack RSK kinases evolved as a mimic of a short linear motif (SLiM) found in proteins related to the RAS-ERK MAP kinase pathway.
Martin Veinstein, Vincent Stroobant, Fanny Wavreil…·Frédéric Sorgeloos
The paper identifies human proteins that interact with RSK kinases via DDVF-like SLiMs, showing pathogens mimic these motifs to alter RAS-ERK MAPK pathway regulation.
6 citations