Frédéric Sorgeloos

This paper identifies a second SLiM in cardiovirus L proteins that enables RSK kinases to target the nuclear pore complex via RAE1 interaction.

This paper introduces a workflow using AlphaFold and MiniPAE to predict and validate novel Small Linear Motif (SLiM)-mediated protein interactions, demonstrating its effectiveness with RSK kinases.

The paper identifies human proteins that interact with RSK kinases via DDVF-like SLiMs, showing pathogens mimic these motifs to alter RAS-ERK MAPK pathway regulation.

This study shows that the porcine sapovirus protease NS6 inhibits type I IFN production by targeting TBK1, revealing a mechanism for immune evasion and establishing a new cell line model for PSaV research.

This study shows that the cGAS-STING pathway restricts noroviruses by detecting leaked genomic and mitochondrial DNA, leading to IFN responses.

This study identifies a conserved C-terminal motif in norovirus VPg that binds to eIF4G HEAT-1 domain, essential for translation initiation and a potential antiviral target.