PhysiologyEuropean Respiratory JournalPeer-reviewed
Pharmacological Inhibition of Epac1 Protects against Pulmonary Fibrosis by Blocking FoxO3a Neddylation
Katherine Jankowski, Sarah-Eve S Lemay, Daniel Lozano‐Ojalvo…·Lahouaria Hadri
This study shows that inhibiting Epac1 with AM-001 reduces fibroblast proliferation and profibrotic markers, protecting against pulmonary fibrosis in mouse models and human lung slices.