Cancer BiologybioRxiv
O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation
L. Ciraku, Z. A. Bacigalupa, J. Ju…·M. J. Reginato
This study identifies OGT's role in regulating GBM acetate metabolism through CDK5-dependent ACSS2 phosphorylation, showing that targeting this pathway inhibits tumor growth.
DOI 10.1038/s41388-022-02237-6