J. Ju

EmbB and EmbC Regulate the Sensitivity of Mycobacterium abscessus to Echinomycin

This study identifies EmbB and EmbC as regulators of Mycobacterium abscessus sensitivity to echinomycin, showing that EmbB mutations can partially compensate for EmbC loss and alter cell wall permeability.

Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria

This study identifies two ilamycin analogs targeting mycobacterial Clp protease components and discovers mutations conferring resistance to these compounds.

Development of Gemcitabine-Modified miRNA Mimics as Cancer Therapeutics for Pancreatic Ductal Adenocarcinoma

Yuen and Hwang et al. developed Gem-modified miRNA mimics that show enhanced efficacy in inhibiting PDAC cell growth and tumor progression with reduced toxicity.

Angiopoietin-like 4 promotes the proliferation and migration of epidermal stem cells and contributes to the re-epithelialization of cutaneous wounds

This study shows ANGPTL4 promotes epidermal stem cell proliferation and migration, enhancing wound re-epithelialization in mice.

Development of a 5-FU Modified miR-129 Mimic as a Therapeutic for Non-Small Cell Lung Cancer

This study develops a 5-FU modified miR-129 mimic that inhibits NSCLC proliferation, induces apoptosis, overcomes drug resistance, and extends survival in vivo without toxicity.

Development of 5-FU-modified tumor suppressor microRNAs as a platform for novel microRNA-based cancer therapeutics

This paper develops 5-FU-modified tumor suppressor miRNAs as a platform for cancer therapeutics, showing increased potency and delivery capability without delivery vehicles.

Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics

This study identifies HCV NS5A inhibitors as SARS-CoV-2 exonuclease inhibitors and shows synergy in combination with polymerase inhibitors to enhance antiviral efficacy.

O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation

This study identifies OGT's role in regulating GBM acetate metabolism through CDK5-dependent ACSS2 phosphorylation, showing that targeting this pathway inhibits tumor growth.

Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude

The paper uses optical tools to show that RhoA activation levels determine distinct cellular responses, with low levels causing focal adhesion disassembly and high levels causing both growth and disassembly.

Sofosbuvir Terminated RNA is More Resistant to SARS-CoV-2 Proofreader than RNA Terminated by Remdesivir

This study compares the resistance of SARS-CoV-2 RNA terminated by Sofosbuvir and Remdesivir to exonuclease proofreading, finding Sofosbuvir-terminated RNA more resistant.

Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures

This paper develops a feeder-free organoid culture system for human distal lung progenitors and demonstrates SARS-CoV-2 infection of club cells in a novel in vitro model.

A Library of Nucleotide Analogues Terminate RNA Synthesis Catalyzed by Polymerases of Coronaviruses Causing SARS and COVID-19

This paper evaluates nucleotide analogues as inhibitors of SARS-CoV and SARS-CoV-2 RdRp, identifying those that terminate RNA synthesis and resist viral exonuclease activity.

Triphosphates of the Two Components in DESCOVY and TRUVADA are Inhibitors of the SARS-CoV-2 Polymerase

The paper shows that the triphosphates of tenofovir and emtricitabine inhibit SARS-CoV-2 RNA-dependent RNA polymerase, suggesting potential use of DESCOVY and TRUVADA as PrEP for COVID-19.

Nucleotide Analogues as Inhibitors of Viral Polymerases

The paper investigates the potential of nucleotide analogues, specifically EPCLUSA, as inhibitors of viral polymerases in coronaviruses like 2019-nCoV, SARS, and MERS.

Functional significance and therapeutic potential of miR-15a mimic in pancreatic ductal adenocarcinoma

This study shows that miR-15a mimic, especially modified with 5-FU, reduces PDAC cell proliferation and tumor growth, suggesting its therapeutic potential and prognostic value.

Cloning, Biochemical Characterization and inhibition of Alanine racemase from Streptococcus iniae

This study characterizes alanine racemase from Streptococcus iniae, identifies inhibitors, and demonstrates their efficacy against both gram-positive and gram-negative bacteria.