Author

W. A. Houry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

A. A. Iwanowicz· 1 shared C. J. Der· 1 shared D. S. Karanewsky· 1 shared E. Holmuhamedov· 1 shared E. J. Iwanowicz· 1 shared E. Leung· 1 shared E. M. J. Fennell· 1 shared H. Ashamalla· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperPharmacology & Toxicology

A. A. Iwanowicz

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivFeb 14, 2022

Characterization of TR-107, a Novel Chemical Activator of the Human Mitochondrial Protease ClpP

E. M. J. Fennell, L. J. Aponte-Collazo, J. D. Wynn…·L. M. Graves

This paper characterizes TR-107, a novel ClpP activator, showing potent antitumor effects against triple-negative breast cancer through mitochondrial metabolic disruption.

DOI 10.1002/prp2.993

humanbulk RNA-seq

𝕏 PostBluesky

BiophysicsbioRxivDec 8, 2019

A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

Z. A. Ripstein, S. Vahidi, W. A. Houry…·L. E. Kay

This study presents cryo-EM structures of the ClpXP complex from Neisseria meningitidis, revealing how ATP hydrolysis couples substrate unfolding and proteolysis.

DOI 10.7554/elife.52158

bacteria (other)cryo-EM

𝕏 PostBluesky