Cancer BiologybioRxivPreprint
Colorectal adenocarcinomas downregulate the mitochondrial Na+/Ca2+ exchanger NCLX to drive metastatic spread
T. Pathak, M. Gueguinou, V. Walter…·M. Trebak
This study shows that reduced NCLX expression in colorectal tumors leads to mtCa2+ overload, promoting metastasis and chemoresistance through mtROS/HIF1 signaling.
DOI 10.1101/2020.05.07.083071